IRTG “Molecular Pathogenesis of Male Reproductive Disorders“

Molecular Pathogenesis of Male Reproductive Disorders


International Research Training Group funded by the German Research Foundation DFG, Justus Liebig University Giessen, Germany and Monash University, Clayton (Melbourne), Australia

Funding period

April 2013 – March 2022

Participating institutions

  • Justus Liebig University Giessen, Germany
    Faculty of Medicine, Faculty of Veterinary Medicine
  • Monash University, Clayton (Melbourne), Australia
    Faculty of Medicine, Nursing and Health Sciences, Monash University Department of Molecular and Translational Research, School of Clinical Sciences and Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute
  • Hudson Institute of Medical Research (affiliated with Monash University)


  • Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
  • Burnet Institute, Centre for Biomedical Research, Melbourne, Australia


Spokesperson Justus Liebig University: Prof. Dr. Andreas Meinhardt
Spokesperson Monash University: Prof. Kate Loveland

Description / aims

The research is focusing around the following two thematic areas (infertility incl. testis and epididymis disorders, prostate disorders) investigation key regulatory mechanisms (local factors incl. activin/TGFβ; inflammation and immunity; sex steroid hormones; genes/epigenetics). Each project is jointly studied by Australian-German investigator pairs (‘tandem projects’). Consequently, all students recruited to this programme will be mutually supervised by scientists from Monash University and Justus Liebig University. PhD studies require a reciprocal visit to the partner institution giving students the opportunity to undertake a joint PhD. Importantly, the research training programme builds on strong translational/clinical exposure and disease models in Germany and on advanced method platform training and technologies at Monash University (e.g. Medical Genomics, Flowcore, Imaging and Bioinformatics Platform Facilities) and access to important and unique transgenic mouse models.


Kügler R, Mietens A, Seidensticker M, Tasch S, Wagenlehner FM, Kaschtanow A, Tjahjono Y, Tomczyk CU, Beyer D, Risbridger GP, Exintaris B, Ellem SJ, Middendorff R
Novel imaging of the prostate reveals spontaneous gland contraction and excretory duct quiescence together with different drug effects
Faseb J, 2017 Oct 31; pii: fj.201700430R. PubMed PMID: 29089445

Michel V, Duan Y, Stoschek E, Bhushan S, Middendorff R, Young JL, Loveland KL, de Kretser DM, Hedger MP, Meinhardt A
Uropathogenic Escherichia coli cause fibrotic remodelling of the epididymis.
J Pathol; 2016 Sep; 240(1):15-24. PubMed PMID:27218225

Lim S, Peng Qu Z, Kortschak RD, Lawrence DM, Geoghegan J, Hempfling A-L, Bergmann M, Goodnow CC, Ormandy CJ, Womg L, Mann J, Scott HS, Jamasal D, Adelson D, O´Bryan MK
HENMT1 and piRNA stability are required for adult male germ cell transposon repression and to define the spermatogenic program in the mouse.
PLoS Genet. 2015 Oct 23;11(10): PubMed PMID: 26496356