Clinical Research Center, Dresden-Munich-Würzburg

CRC/Transregio 205 „The Adrenal: Central Relay in Health and Disease”


Funded by the Deutsche Forschungsgemeinschaft (DFG)


Spokesperson: Prof. Dr. med. Stefan R. Bornstein (MKIII)
Coordinator: Eva Spickenheuer

Description / aims

The Clinical Research Center/Transregio about the adrenal gland (CRC/TRR 205) unites all relevant disciplines concerning the adrenal research including the neuronal, immunological and endocrinological regulation. Eight different institutes located in Dresden, Munich and Würzburg are jointly working not only on the basic and translational research but also on the clinical adrenal research.

Goal is to explore the fundamental role of the adrenal gland in the context of dysfunction, tumours and systemic diseases. This research work makes it possible to define the central role of the adrenal gland in the bodies stress system connected to frequent metabolic and inflammatory diseases.

Patients suffering from adrenal diseases, such as Morbus Cushing, CONN- Syndrome, Morbus Addison and pheochromocytoma, will be treated at the adrenal center in Dresden. Optimal care will be guaranteed due to the close cooperation of clinical experts and researchers of the clinical research center.

Top publications of the CRC/TRR 205

1. Case 8-2018: A Woman With Shock and Labile Blood Pressure
Jacques Lenders , Graeme Eisenhofer
N Engl J Med. 2018 May 31;378(22):2146.doi: 10.1056/NEJMc1804983.
IF 70.670 (2019)

2. Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis
Ben Wielockx, Tatyana Grinenko, Peter Mirtschink, Triantafyllos Chavakis
Cells. 2019 Feb 13;8(2):155.doi: 10.3390/cells8020155.
IF 36.216 (2018)

3. Novel Medications Inducing Adrenal Insufficiency
Stefan R Bornstein, Tobias D Bornstein, Cynthia L Andoniadou
Nat Rev Endocrinol. 2019 Oct;15(10):561-562.doi: 10.1038/s41574-019-0248-9.
IF 24.646 (2019)

4. Adrenocortical Carcinoma - Towards Genomics Guided Clinical Care
Joakim Crona, Felix Beuschlein
Nat Rev Endocrinol. 2019 Sep;15(9):548-560.doi: 10.1038/s41574-019-0221-7.
IF 24.646 (2019)

5. DEL-1 Promotes Macrophage Efferocytosis and Clearance of Inflammation
Ioannis Kourtzelis, Xiaofei Li, Ioannis Mitroulis, Daniel Grosser, Tetsuhiro Kajikawa, Baomei Wang, Michal Grzybek, Janusz von Renesse, Aleksander Czogalla, Maria Troullinaki, Anaisa Ferreira, Christian Doreth, Klara Ruppova, Lan-Sun Chen, Kavita Hosur, Jong- Hyung Lim, Kyoung-Jin Chung, Sylvia Grossklaus, Anne Kathrin Tausche, Leo A B Joosten, Niki M Moutsopoulos, Ben Wielockx, Antonio Castrillo, Jonathan M Korostoff, Ünal Coskun, George Hajishengallis, Triantafyllos Chavakis
Nat Immunol. 2019 Jan;20(1):40-49.doi: 10.1038/s41590-018-0249-1. Epub 2018 Nov 19.
IF 23.530 (2019)